An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients.

نویسندگان

  • Junko Inagaki
  • Mayumi Sugiura-Ogasawara
  • Motoyoshi Nomizu
  • Mikiya Nakatsuka
  • Katsuo Ikuta
  • Nobuharu Suzuki
  • Keiko Kaihara
  • Kazuko Kobayashi
  • Tatsuji Yasuda
  • Yehuda Shoenfeld
  • Koji Aoki
  • Eiji Matsuura
چکیده

BACKGROUND Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. METHODS Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. RESULTS Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-alpha1 chain G domain. mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions. CONCLUSIONS IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

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عنوان ژورنال:
  • Human reproduction

دوره 18 3  شماره 

صفحات  -

تاریخ انتشار 2003